Psych #
Delerium #
- EtOH usually visusal, small “creepy crawlies” vs normal which is usually “larger” things
Dementia #
Alzheimer: short term memory loss, apraxia, no motor signs, late hallucinations/delusions Vascular dementia: “step wise” decline, h/o or risk factor for TIA/stroke Lewy body: psychosis early, Parkinson’s features, falls
Agitation and Behavioral Distrubances #
- Abilify (aripiprazole)
- Start 5-10mg daily
- Don’t use more than 15mg qday
- Risperdal (risperidone)
- Start low (1-2mg)
- Usual dose 4-6mg
- Depakote (valproic acid)
- Can be added to either of the above
- Start at 500mg XR
- Check level and titrate up to about 50-110 after 4-5 days
Preference:
- Abilify
- Abilify + Depakote
- Risperdal
- Risperdal + Depakote
Treatment #
- Cholinesterase inhibitors
- Donepezil, Rivastigmine, Galantamine
- AEs: Bradycardia, weight loss, GI intolerance, increased secretion (avoid with GI issues, COPD/asthma)
- Memantine
PHQ-9 Screener #
SIG E CAPS >5 = positive
Sleep
Interest
Guilt/Worthlessness
Energy
Concentration
Appetite
Psychomotor (restless/lethargic)
Suicidality
Scoring #
0-4: None
5-9: Mild (positive)
10-14: Moderate
15-19: Moderate Severe
20+: Severe
GAD-7 Screener #
Scores 10 and above with roughly 75-85% sensitvity and specificity for one of GAD, panic disorder, or social anxiety disorder.
Scoring #
- <e;4: Minimal
- 5-9: Mild
- 10-14: Moderate
- >e;15: Severe
Bipolar Screen #
Ask “Ever felt so happy/energetic that friends said you were talking to fast or too hyper?”
If yes => DIG FAST
Distractibility
Indescretion (excessive involvement in pleasurable activities)
Grandiosity
Flight of ideas
Activity incrase
Sleep deficit
Talkativeness (pressured speech)
Borderline Screener (PD criteria) #
Identity problems
Disordered affect
Empty feeling
Suicidal behavior
Paranoia
Abandonment terror
Impulsivity
Rage
Relationship Instability
>2 → positive
MiniCog Exam #
76% sensitive, 89% specific
- Remember 3 items
- Draw clock at 10 past 11
- Recall 3 items
If 0/3 on recall => Dementia
If 3/3 on recall => No dementia
Else if clock ok => No dementia
Anxiety Treatments #
- Atarax (Hydroxyzine): 50-100mg 4x daily (QiD)
- Gabapentin: 300mg TID prn
- Risperidone 1-2mg (start at 0.5mg) daily
- Can cause gynecomastia, let patients know and if see any changes dc med (reverts)
- Seroquel
- 1/2 tab (12.5mg) prn for anxiety
- full tab (25mg) at bedtime
Alcohol Abuse Screener (CAGE) >2 = positive #
Cut down
Annoyed
Guilt
Eye-opener
SSRIs #
Start with (if starting from scratch in generic patient):
- Sertaline (Zoloft)
- Least side effects
- Escalitopram (Lexapro)
- Fluoxetine (Prozac)
SNRIs #
If eating too much as part of depression/anxiety, SNRIs are good choice. NE part “shuts down” GI system a bit (fight/flight).
Serotonin/NE ratio -> more NE, the more “uplifitng” the med—in theory…
Med | Trade Name | Serotonin/NE ratio |
---|---|---|
Venlafaxine | Effexor | 30/1 |
Desvenlafaxine | Pristiq | 10/1 |
Duloxetine | Cymbalta | 10/1 |
Levomilnacipran | Fetzima | 1/2 |
[Paper with annotations](/literature/Serotonin Norepinephrine Reuptake Inhibitors- A Pharmacological Comparison.pdf) and link to original.